Endocrine Abstracts

Introduction: Proton magnetic resonance spectroscopy (1H-MRS) is a sensitive, non-invasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing’s syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochemical cure.Objective: To investigate metabolites in the hippocampi of CS patients and controls, using 1</sup...

Introduction: Patients with Cushing’s syndrome might present a variety of brain alterations. There is however little evidence from MRI studies demonstrating atrophy of either frontal or medial temporal brain regions.Aims: To study cortical alterations (decreased cortical thickness) on MRI in patients with Cushing’s syndrome (CS), as compared to controls (C), and long-standing major depressive disorder (MDD).Material and m...